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By redirecting the silencing activity of the host’s own non-coding genes, GEiGS® introduces novel RNAi activity with highly programmable potency and tissue specificity. This elegant approach requires only minimal changes to the host’s genome (less than 20 nucleotides), thus avoiding transcriptional gene silencing and allowing for highly stable RNAi activity over time and across generations.
GEiGS® can be used to redirect the silencing activity of the host’s native non-coding genes towards well characterized and highly conserved viral, fungal or pest genes. This distinctly direct approach significantly accelerates product development time while minimizing pleiotropic effects associated with editing the host’s coding genes.
GEiGS® technology does not involve the insertion of DNA sequences from other organisms (‘Foreign DNA’) into the host genome and does not impact the sequence of proteins. These factors allow for a non-GM classification in multiple major markets and a more streamlined regulatory approval process.
GEiGS® is not dependent on any one specific gene editing tool, but instead can be deployed by using a broad range of different nucleases. This provides the user with freedom to choose which gene editing tools they use to implement GEiGS® edits – tools that may already be applied in their existing pipelines.
Find out how GEiGS® technology can benefit you
We collaborate with world-leading companies and academic institutions, enabling them to access our pioneering GEiGS® technology to address some of the most pressing agricultural production challenges.
Contact us today to discuss GEiGS® licensing and service options and join us in driving innovation forward.
geigs@tropic.bio +44 (0)1603 274441