Gene editing and RNAi combined in one versatile platform

  • Gene Editing icon

    GEiGS® uses universal gene editing tools such as CRISPR, to minimally edit the host’s own non-coding genes and redirect their silencing activity (RNAi) towards any desired target gene or gene family.

  • GEiGS-Biocompute Icon

    GEiGS-BioCompute is the cutting edge bioinformatics platform that designs gene editing solutions to allow precise and effective implementation of GEiGS® technology.

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Key benefits of GEiGS®

  • Key Benefits Icon
    Precise, predictable, and stable tuning of target gene expression

    By redirecting the silencing activity of the host’s own non-coding genes, GEiGS® introduces novel RNAi activity with highly programmable potency and tissue specificity. This elegant approach requires only minimal changes to the host’s genome (less than 20 nucleotides), thus avoiding transcriptional gene silencing and allowing for highly stable RNAi activity over time and across generations.

  • Key Benefits Icon
    Accelerated development of critical disease and pest resistance traits

    GEiGS® can be used to redirect the silencing activity of the host’s native non-coding genes towards well characterized and highly conserved viral, fungal or pest genes. This distinctly direct approach significantly accelerates product development time while minimizing pleiotropic effects associated with editing the host’s coding genes.

  • Key Benefits Icon
    Favourable regulatory classification in multiple markets

    GEiGS® technology does not involve the insertion of DNA sequences from other organisms (‘Foreign DNA’) into the host genome and does not impact the sequence of proteins. These factors allow for a non-GM classification in multiple major markets and a more streamlined regulatory approval process.

  • Key Benefits Icon
    Universal platform that works with existing gene editing tools

    GEiGS® is not dependent on any one specific gene editing tool, but instead can be deployed by using a broad range of different nucleases. This provides the user with freedom to choose which gene editing tools they use to implement GEiGS® edits – tools that may already be applied in their existing pipelines.

Find out how GEiGS® technology can benefit you

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How our users benefit from using the GEiGS® platform

Banana
Banana

Panama disease, caused by tropical race 4 (TR4) of the Fusarium wilt fungus, is a devastating disease that poses an urgent threat to global banana production.

Tropic developed the GEiGS® technology platform to address this critical fungal disease and is now developing commercial banana lines that are resistant to TR4.

Row Crops
Row Crops

Row crops including wheat, corn, soybean and rice, account for the majority of planted cropland globally.

As pressures mount to develop more sustainable approaches to protect against yield losses attributable to pests and diseases, GEiGS® offers an attractive solution to address these challenges.

Poultry
Poultry

Avian Influenza virus (AIV) is a deadly disease that primarily affects bird species and costs the poultry industry billions of dollars during each outbreak. This disease also threatens human health as the virus can be transferred from birds to humans, where it has been documented to cause severe illness and in some cases fatality.

GEiGS® is now being used to address this disease through the development of chickens that are resistant to AIV.

Livestock
Livestock

Infectious diseases of livestock are a major threat to animal health and welfare and their effective control is crucial for safeguarding global food supplies. Furthermore, several of these diseases are transmissible between animals and humans posing significant threats to human health.

GEiGS® is being used as a means to accelerate genetic improvement in livestock species to help farmers in tackling animal disease while improving welfare.

Our global collaborators include

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Interested in partnering with us?

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We are excited to work with Tropic and explore the application of GEiGS® technologies in accelerating genetic improvement for farmers and tackling animal disease and suffering.

Genus

A world-leading animal genetics company

GEiGS-BioCompute streamlines the gene editing process significantly, enabling highly customised and effective applications.

Dr. Eyal Maori

CSO, Tropic

Our R&D teams must continue to innovate to address the most pressing challenges in agriculture, so we welcome GEiGS® to accelerate the delivery of sustainable trait solutions to farmers.

BASF

Agricultural Solutions

GEiGS® radically expands our ability to develop and commercialize non-transgenic disease resistance traits.

Gilad Gershon

CEO, Tropic

Access the GEiGS® platform

We collaborate with world-leading companies and academic institutions, enabling them to access our pioneering GEiGS® technology to address some of the most pressing agricultural production challenges.

Contact us today to discuss GEiGS® licensing and service options and join us in driving innovation forward.

geigs@tropic.bio +44 (0)1603 274441
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Latest GEiGS® News

Latest GEiGS® News

Gene Editing induced Gene Silencing

from Tropic

Contact us
geigs@tropic.bio +44 (0)1603 274441