Tropic’s non-browning gene-edited banana cleared for production in the Philippines

Our team at @Tropic is pleased to share the news that our non-browning banana received a non-GMO exemption decision from Philippines Department of Agriculture-Bureau of Plant Industry.  This is the first gene-edited product to go through the Philippine’s newly defined gene editing regulatory determination process.  With  this determination the Tropic non-browning can be freely imported and propagated in the Philippines..

Tropic’s Chief Technology Officer Dr. Ofir Meir stated,  “The Philippines government has implemented a science-based, transparent, and efficient process for assessing the safety of gene-edited plants.  This is exactly the type of system that encourages companies like Tropic to invest in innovative technologies to develop sustainable solutions for Filipino farmers.”   

Tropic’s non-browning bananas have the potential to significantly reduce food waste and CO2 emissions along the supply chain by more than 25%, as over 60% of exported bananas go to waste before reaching the consumer. This innovative product can support a reduction in CO2 emissions equivalent to removing 2 million passenger vehicles from the road each year.

Tropic plans to introduce several important products in the Philippines over the next decade, starting with the non-browning banana. The Philippines is the top producer and exporter of bananas in Southeast Asia, but its global market share has decreased due to the prevalence of Panama disease Tropic Race 4, which threatens 80% of global banana production. Tropic is using gene editing technology to develop disease-resistant bananas that can solve for Panama Disease Tropical Race 4. The clear and predictable regulatory framework for gene-edited products established by the Filipino government will encourage investment and R&D in the country’s banana sector.

At Tropic, we are driven by the impact of our work, specifically by improving the livelihood of growers and developing plant varieties which address our planet’s most pressing challenges.

 

About Tropic

Tropic is a pioneering agricultural-biotechnology company dedicated to the development of healthier, more robust, high-performing varieties of tropical crops with a vision to becoming a world leading technology-forward seed business. The company’s core crop portfolio focusses on banana, coffee and rice, which together provide a source of livelihood to over half a billion people worldwide. The booming population brings a drastic food security and supply crisis which is intensified by climate change and economic factors.

Tropic is working closely with growers to address these critical pressures and, in doing so, promotes consumer wellbeing and positive grower economics, while addressing crop stability and unmet nutritional needs. The company’s core mission is developing sustainable crop products better suited to the local growing environment but also easier to cultivate, more profitable for farmers and healthier for consumers – thereby benefitting the entire food supply chain.

British Sugar and Tropic announce strategic collaboration to sustainably tackle devastating disease of sugar beet

PRESS RELEASE

British Sugar, a leading producer of sugar for the UK food and beverage markets, has entered into a strategic collaboration with Tropic to deploy our ground-breaking GEiGS® technology in sugar beet. The program is set to develop high-performance sugar beet varieties that can sustainably withstand viral diseases, doing away with the need for environmentally damaging pesticides.

Climate change presents critical challenges and has been implicated as a driver for crop losses due to increasingly frequent outbreaks of pests and diseases. One such problem is Virus Yellows (VY) disease of sugar beet, which has caused unprecedented crop damage with growers reporting yield losses of up to 80% in recent years. VY disease is transmitted by aphids which have traditionally been controlled by neonicotinoid insecticide treatments. However, concerns about the impact of these insecticides on other insects have prompted regulatory changes severely restricting their use.

“We have a need to develop more sustainable solutions for sugar beet growers. In securing long-term sugar beet yields through disease-resistant seed, this venture will play a crucial role in reducing our reliance on pesticides, while safeguarding domestic sugar beet farming and the livelihoods of several growers and communities in the UK” says Daniel Green, Agricultural Director at British Sugar.

This synergistic alliance between two British companies will focus on accelerating delivery of improved sugar beet varieties through Tropic’s proprietary GEiGS® platform.

“The GEiGS® technology, which combines elements of precision gene editing and a naturally occurring immunity mechanism known as gene silencing, is a game changing platform allowing us to develop crops that are better able to withstand disease- and climate- pressures to enable much more sustainable cropping practices” says Ofir Meir, Chief Technology Officer at Tropic.

 

About British Sugar

British Sugar, the leading sugar producer in Britain, is a homegrown industry working in partnership with over 3,000 growers and customers to deliver world-class product worldwide, including over 50% of sugar consumed through the British and Irish food & beverage industry. The company boasts sole processing rights of the UK’s entire sugar beet crop, turning over around eight million tonnes of sugar beet and producing up to 1.2 million tonnes of sugar each year. Their innovative approach to manufacturing also enables opportunities to create a range of co-products from power generation and bioethanol to animal feed and much more.

 

About Tropic

Tropic is a pioneering agricultural-biotechnology company dedicated to the development of healthier, more robust, high-performing varieties of tropical crops with a vision to becoming a world leading technology-forward seed business. The company’s core crop portfolio focusses on banana, coffee and rice, which together provide a source of livelihood to over half a billion people worldwide. The booming population brings a drastic food security and supply crisis which is intensified by climate change and economic factors.

Tropic is working closely with growers to address these critical pressures and, in doing so, promotes consumer wellbeing and positive grower economics, while addressing crop stability and unmet nutritional needs. The company’s core mission is developing sustainable crop products better suited to the local growing environment but also easier to cultivate, more profitable for farmers and healthier for consumers – thereby benefitting the entire food supply chain.

 

About GEiGS®

GEiGS® (Gene Editing induced Gene Silencing) technology utilizes established genome editing tools (e.g., CRISPR, TALEN) to make precise and specific changes to only a few nucleotides within non-coding genes of a host organism. These changes redirect RNA interference (RNAi, also Gene Silencing) activity of non-coding genes towards desired target genes, suppressing their activity. Target genes can include the host’s own genes, or gene-families, to finely tune their expression to a new desired level. Further, GEiGS® can be used to activate defense against pathogens and pests (e.g., viruses, insects and fungi) by redirecting RNAi activity towards pathogen and pest genes. GEiGS® does not depend on the introduction of foreign genes into the host genome, and thus the approach will be considered as non-GMO in multiple regions.

For more information, please visit the GEiGS®  website

Genus Plc and Tropic announce extension and expansion of trait development collaboration

JOINT PRESS RELEASE:

Genus Plc (“Genus”), a world leader in animal genetic improvement, and Tropic, a pioneering agricultural-biotechnology company, today announce that they are extending and expanding their collaboration for the application of Tropic’s Gene Editing induced Gene Silencing (GEiGS®) technology in porcine and bovine genetics.

Since the collaboration started in June 2020, Tropic has delivered multiple sets of GEiGS® solutions for Genus to evaluate, which is a critical step in the development of resistance traits to several devastating livestock diseases. Experimental validations of the GEiGS® solutions conducted by Genus’ scientists have demonstrated effective silencing of specific target genes.

The extended collaboration will enable Genus and Tropic to explore additional traits that will be based on the GEiGS® platform, to expand animal welfare traits in bovine and porcine species.

Elena Rice, Chief Scientific Officer at Genus stated: “We are excited to continue our collaboration with Tropic Biosciences and expand validation of GEiGS® solutions to address critical diseases in animals.”

Jack Peart, Chief Business Officer at Tropic Biosciences commented: “Our progress with Genus demonstrates the power of the GEiGS® technology in addressing critical diseases in animals, adding to the growing list of animal and plant species where GEiGS® is demonstrating its effectiveness. We are excited to continue the collaboration with the incredible Genus team, and to further harness cutting edge innovation to improve animal welfare and promote sustainable practices in the industry.”

For further information, please contact us.

 

About Genus Plc

Genus is a world-leading animal genetics company. Genus creates advances to animal breeding and genetic improvement by applying biotechnology and sells added value products for livestock farming and food producers. Its technology is applicable across livestock species and is currently commercialised by Genus in the dairy, beef and pork food production sectors.

Genus’s worldwide sales are made in over seventy-five countries under the trademarks ‘ABS’ (dairy and beef cattle) and ‘PIC’ (pigs) and comprise semen, embryos and breeding animals with superior genetics. Genus’s customers’ animals produce offspring with greater production efficiency, and quality, and use these to supply the global dairy and meat supply chains.

The Group’s competitive edge has been created from the ownership and control of proprietary lines of breeding animals, the biotechnology used to improve them and its global supply chain, technical service and sales and distribution network. With headquarters in Basingstoke, United Kingdom, Genus companies operate in over twenty-five countries on six continents, with research laboratories located in Madison, Wisconsin, USA.

This announcement is available on the Genus website www.genusplc.com

 

About Tropic

Tropic is one of the leading agricultural gene-editing companies globally and focuses on the development and commercialization of high-performing varieties of tropical crops, namely coffee, bananas and rice. It employs over 130 industry-leading professionals

For more information, please visit www.tropic.bio

 

About GEiGS®

GEiGS® (Gene Editing induced Gene Silencing) technology utilizes established genome editing tools (e.g. CRISPR, TALEN) to make precise and specific changes to only a few nucleotides within non-coding genes of a host organism. These changes redirect RNA interference (RNAi, also Gene Silencing) activity of non-coding genes towards desired target genes, suppressing their activity. Target genes can include the host’s own genes, or gene-families, to finely tune their expression to a new desired level. Further, GEiGS® can be used to activate defense against pathogens and pests (e.g. viruses, insects and fungi) by redirecting RNAi activity towards pathogen and pest genes. GEiGS® does not depend on the introduction of foreign genes into the host genome, and thus the approach will be considered as non-GMO in multiple regions.

Positive response from USDA on regulatory status using GEiGS®

PRESS RELEASE:

Tropic Biosciences Obtains Positive Response from USDA-APHIS on Regulatory Status of a Product Developed Using its GEiGS® (Gene Editing Induced Gene Silencing) Technology

Tropic Biosciences (“Tropic”), a pioneering agricultural-biotechnology company dedicated to the development of high-performance tropical crops, announced today that it has received confirmation that potatoes with reduced browning, developed by GEiGS®-mediated silencing of polyphenol oxidase-5 (Ppo5) transcripts, were determined to be exempted from regulation by the USDA. Tropic made a submission to the USDA requesting confirmation of regulatory status for this product in May 2021.  The USDA-APHIS response indicated that the plant lines do not meet the definition of a regulated article under 7 CFR Part 340 regulations. Tropic’s submission along with the USDA-APHIS BRS response is posted on the USDA’s website.

“This is the first regulatory assessment of a product based on our proprietary GEiGS® technology and the confirmation that this product is not regulated by USDA is an important step in bringing our crop products to market”, said Gilad Gershon, CEO of Tropic Biosciences.

Tropic Biosciences is using GEiGS® to develop valuable traits in banana, coffee and rice. As an example, GEiGS® enables Tropic Biosciences to develop novel banana varieties that are resistant to Panama Disease (TR4), a devastating fungal disease that threatens global banana production. Tropic Biosciences has also entered into licensing agreements with multiple leading global agribusinesses enabling them to use the platform to develop disease resistance, quality and welfare traits across crop, livestock and aquaculture species.

 

About Tropic Biosciences

Tropic Biosciences is one of the leading agricultural gene-editing companies globally, and focuses on the development and commercialization of high-performing varieties of tropical crops, namely coffee, bananas and rice. It employs over 110 industry-leading professionals and is headquartered at the renowned Norwich Research Park.

For more information please visit www.tropicbioscience.com

 

About GEiGS®

GEiGS® (Gene Editing induced Gene Silencing) technology utilizes established genome editing tools (e.g. CRISPR, TALEN) to make precise and specific changes to only a few nucleotides within non-coding genes of a host organism. These changes redirect RNA interference (RNAi, also Gene Silencing) activity of non-coding genes towards desired target genes, suppressing their activity.

Target genes can include the host’s own genes, or gene-families, to finely tune their expression to a new desired level. Further, GEiGS® can be used to activate defense against pathogens and pests (e.g. viruses and fungi) by redirecting RNAi activity towards pathogen and pest genes. GEiGS® does not depend on the introduction of foreign genes into the host genome, and thus the approach will be considered as non-GMO in multiple regions.

Key benefits of GEiGS®

  • Key Benefits Icon
    Precise, predictable, and stable tuning of target gene expression

    By redirecting the silencing activity of the host’s own non-coding genes, GEiGS® introduces novel RNAi activity with highly programmable potency and tissue specificity. This elegant approach requires only minimal changes to the host’s genome (less than 20 nucleotides), thus avoiding transcriptional gene silencing and allowing for highly stable RNAi activity over time and across generations.

  • Key Benefits Icon
    Accelerated development of critical disease and pest resistance traits

    GEiGS® can be used to redirect the silencing activity of the host’s native non-coding genes towards well characterized and highly conserved viral, fungal or pest genes. This distinctly direct approach significantly accelerates product development time while minimizing pleiotropic effects associated with editing the host’s coding genes.

  • Key Benefits Icon
    Favourable regulatory classification in multiple markets

    GEiGS® technology does not involve the insertion of DNA sequences from other organisms (‘Foreign DNA’) into the host genome and does not impact the sequence of proteins. These factors allow for a non-GM classification in multiple major markets and a more streamlined regulatory approval process.

  • Key Benefits Icon
    Universal platform that works with existing gene editing tools

    GEiGS® is not dependent on any one specific gene editing tool, but instead can be deployed by using a broad range of different nucleases. This provides the user with freedom to choose which gene editing tools they use to implement GEiGS® edits – tools that may already be applied in their existing pipelines.

Find out how GEiGS® technology can benefit you

How our users benefit from using the GEiGS® platform

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Access the GEiGS® platform

We collaborate with world-leading companies and academic institutions, enabling them to access our pioneering GEiGS® technology to address some of the most pressing agricultural production challenges.

Contact us today to discuss GEiGS® licensing and service options and join us in driving innovation forward.

geigs@tropic.bio +44 (0)1603 274441